DYNAMICS OF CHANGES IN TEMPERATURE PARAMETERS IN BIOLOGICAL TISSUES UNDER LASER RADIATION OF DIFFERENT WAVE LENGTHS
Keywords:Laser radiation, Regeneration, Skin types, Laser therapeutic apparatus
Background. The use of lasers is one of the promising directions in the development of therapy and surgery. The effect of low-intensity laser radiation (LR) in therapeutic doses activates regenerative processes in tissues, which allows stimulating regeneration processes due to the intensification of microcirculation of metabolic processes and also has an effect on neuro-reflex and humoral pain mechanisms and on pain receptors. There is a need to clearly establish the LR parameters that are important in the development and receipt of effective results of therapy. Diagnostics in vivo allows getting the opposite answer about the reaction of the body to radiation with different dose indicators, power density and wavelength without damaging the biological tissue.
Objective. Since laser devices are used for many physiotherapeutic and diagnostic procedures, for the correct application of low-intensity LR, it is necessary to take into account all the structural features of the influence zone, as an example, human skin and the processes of interaction of this LR with layers of biological tissues. Under the influence of LR begins the course of a wide range of photophysical and photochemical changes, occurs the temperature rise on the surface of the irradiated skin and physicochemical transformations. The main purpose of the work was to determine the dynamics of changes in the temperature of the skin under the influence of LR.
Methods. It was justified the use of mathematical dependence to determine the required dose of LR and a mathematical model for calculating the change in skin temperature under the influence of LR. An experiment was performed comparing the results of the calculation by mathematical model and the results of the experiment on the LR influence with wavelengths of 0.66 μm, 0.63 μm, and 0.46 μm on the nature and dynamics of temperature processes in the upper layers of the skin.
Results. As a general result, data on the dynamics of changes in the temperature of the skin under the influence of LR are obtained. The results of the experiments and their comparison with the calculations of the mathematical model showed that there is a dependence of the temperature change on the structure and parameters of biological tissue, the power density of the LR, the radiation dose and the exposure time.Conclusions.According to the results of the work, it was concluded that a higher intensity of heat removal occurs in the skin of living tissues. This is mainly due to the microcirculation of organic liquids and blood.
M. Tereshchenko et al., Biophysics. Kyiv, Ukraine: Polytechnika, 2019. Available: http://ela.kpi.ua/handle/123456789/27589
G. Tymchik et al., “Investigation thermal conductivity of biological materials by direct heating thermistor method”, in Proc. IEEE 38th Int. Conf. Electronics and Nanotechnology (ELNANO), Kyiv, 2018, pp. 429–434. doi: 10.1109/ELNANO.2018.8477460
G. Tymchik et al., “Monitoring of temperature changes during laser therapy”, Bulletin of Kyiv Polytechnic Institute. Series Instrument Making, vol. 47, pp. 156–162, 2014.
M. Kokodiy et al., “Thermal processes in human skin during laser pulse irradiation”, Photobiology and Photomedicine, vol. 24, pp. 69–72, 2018.
G. Tymchik et al., “Research of the influence of laser radiation on temperature processes in biological tissues”, Bulletin of Kyiv Polytechnic Institute. Series Instrument Making, vol. 49, pp. 153–158, 2015.
A. Pushkareva, Methods of Mathematical Modeling in Optics of Biological Tissue. Saint Petersburg, Russia: SPbSU ITMO, 2008.
O. Shmendel et al., “Processes of changes of temperature gradients in biological tissues under the action of laser radiation”, in Proc. XII Conf. Looking into the Future of Instrument Making, Kyiv, Ukraine, 2019, pp. 337–340.
L.E. Dolotov et al., “Design and evaluation of a novel portable erythema-melanin-meter”, Lasers in Surgery and Medicine, vol. 34, pp. 127–135, 2004, doi: 10.1002/lsm.10233
A. Dunaev and S. Korndorf, “Control of laser radiation power absorbed in the epidermis during low-intensity laser therapy”, Vestnik Novych Medicinskich Technologyi, vol. 9, no. 4, pp. 63–66, 2002.
Guide on Operation “Lika Therapevt M”. Cherkasy, Ukraine: PSIE “Photonica Plus”, 2016.
M. Kokodiy et al., “Thermal processes in the human skin irradiated with LEDs”, in Proc. XLV Int. Conf. Application of Lasers in Medicine and Biology, Kharkiv, Bukovel, Ukraine, 2016, pp. 124–8.
S. Matvienko et al., “Influence of convection processes in a liquid on the error of measurement of thermal conductivity by the method of direct heating of a thermistor”, Naukovi Visti NTUU KPI, no. 4, pp. 121–130, 2017. doi: 10.20535/1810-0546.2017.5.107938
S. Matvienko et al., “Investigation of thermal conductivity of inhomogeneous biological solutions by the method of direct heating of the thermistor”, in Proc. X Int. Conf. Instrumentmaking–2017, Minsk, Republic of Belarus, 2017, pp. 110–111.
V. Shvidky and M. Tereshchenko, “Dynamics of changes in laser radiation parameters in biological tissues”, Bulletin of Kyiv Polytechnic Institute. Series Instrument Making, vol. 54, no. 2, pp. 111–117, 2017. doi: 10.20535/1970.54(2).2017.119570
M. Tereshchenko et al., “Using the CARDIOMOOD hardware and software complex in estimating the effect of laser radiation on the state of the autonomic nervous system of a person”, Bulletin of Kyiv Polytechnic Institute. Series Instrument Making, vol. 50, no. 2, pp. 160–169, 2015.
D. Sliney et al., Safety with Lasers and Other Optical Sources: A Comprehensive Handbook. New York: Springer Science+Business Media, 1980. doi: 10.1007/978-1-4899-3596-0
S. Hellwig et al., “Aktueller Stand der Lasertherapie in der Dermatologie”, Hautarzt, Germany: Springer-Verlag, 1998, pp. 690–704. doi: 10.1007/s001050050811
M.O. Bodendorf et al., “Fraktionale Lasertherapie der Haut”, J. Compilation, vol. 7, no. 4, pp. 301–308, 2009. doi: 10.1111/j.1610-0387.2008.06845.x
R. Webb et al., “Thermal transport characteristics of human skin measured in vivo using ultrathin conformal arrays of thermal sensors and actuators”, PLoS ONE, vol. 10, no. 2, 2015. doi: 10.1371/journal.pone.0118131
F.J.C. Lima et al., “Use alone or in combination of red and infrared laser in skin wounds”, J. Lasers. Med., vol. 5, no. 2, pp. 51–57, 2014.
S. Moskvin, “Low-level laser therapy in Russia: history, science and practice”, Lasers Med. Sci., vol. 8, no. 2, pp. 56–65, 2017.
V.G. Petruk et al., “Modelling of spectral characteristics of biological tissues skin layer of the epidermis as objects of biomedical diagnostics”, Visnyk Khmelnytskogo Nationalnogo Universitetu. Ser. Technichni Nauki, no. 2, pp. 218–222. 2015.
P. Oltulu et al., “Measurement of epidermis, dermis, and total skin thicknesses from six different body regions with a new ethical histometric technique”, Turk. J. Plast. Surg., vol. 26, pp. 56–61, 2018. doi: 10.4103/tjps.tjps_2_17
P. Avci et al., “Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring”, Semin. Cutan. Med. Surg., vol. 32, pp. 41–52, 2013.
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